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This laid the foundation for tobacco harm reduction (THR), which relies on the fundamental principle that both the individual- and population-level health impacts of cigarette smoking can be reduced by the development of, and smoker access to, novel nicotine and tobacco products which deliver nicotine but in the reduced presence, or absence, of the chemicals responsible for smoking-related disease

85 Systemic glucocorticoids are recommended for the treatment of exacerbations and reduce treatment failure and relapse rates by 1 month, shorten hospital length of stay and improve lung function and symptoms in patients with COPD

Therefore, a potential for interaction with antidiabetic drugs metabolized by this isoenzyme exists (Hesse et al., 2000), suggesting that bupropion could have direct or indirect influences on glucose regulation or insulin sensitivity