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Supplementary material The Supplementary Material for this article can be found online at: SUPPLEMENTARY FIGURE S1 The beta diversity of the CTLs microbiota is based on the binary jaccarad distance and bray curtis distance

From 2011 to 2019, the percentage of high school students who used e-cigarettes increased from 1.5% to 27.5% and from 0.6% to 10.5% among middle schoolers

By constructing a multifactorial Cox proportional risk model, after adjusting for other relevant influencing factors, we found that the incidence of HUA increased by 37.7% in smokers compared with non-smokers, and by 53.4% in smokers with smoking index 601 compared with non-smokers, and was not affected by sex, whether a woman was menopausal, BMI, and alcohol consumption