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The increase in plasma non-esterified fatty acid (NEFA) after intraperitoneal nicotine administration in HFD-fed mice indicates the role of nicotine in promoting lipolysis

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(2000) investigated the effects of nicotine exposure on oocyte maturation in vivo in mice ovaries and reported that dosages of 10.0 mg/kg nicotine caused premature centromere separation and premature anaphase, and consequently advanced ovarian maturation in addition to reduced proportions of ovulated oocytes by approximately 50% compared to control groups

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