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Last but not least, ENDS exposure induces cell death in epithelium and endothelium in the lung of ENaC-overexpressing mice ( Figure 8 )

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Structured monitoring of: (a) nicotine withdrawal symptoms or 'mood and experiences' (Segan Reference Segan, Baker and Turner2017), using the 8-item Minnesota Nicotine Withdrawal Scale (Hughes Reference Hughes2007a): anger/irritability/frustration anxiety or nervousness depression/sad mood desire/craving to smoke difficulty concentrating increased appetite/hunger/weight gain insomnia/sleep problems/awakening at night restlessness/impatience (b) the most common adverse side-effects of psychiatric medications (Lapshin Reference Kay-Lambkin, Edwards and Baker2006), or 'possible side-effects' (Segan Reference Segan, Baker and Turner2017): dry mouth or increased salivation increased thirst headache nausea drowsiness, tiredness, fatigue increased sleep blurred vision dizziness increased sweating In the case of anxiety, depression, low mood and stress, the five areas of the CBT model can help us understand that these conditions and their associated feelings can be a trigger for smoking