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This framework evaluates several key aspects: biological plausibility (i.e., whether the upstream and downstream events are mechanistically linked), the essentiality of key events (i.e., whether blocking an upstream KE prevents the occurrence of downstream events), empirical support (i.e., consistency with doseresponse, temporal, and incidence patterns), and overall coherence across studies ( In this study, KERs were evaluated through an automated, literature-based approach using the eventevent module of AOP-helpFinder