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In an important study by Khokhar and Tyndale, the authors found that 7 days of nicotine treatment increased CYP2B expression in the brain, but not liver, and surprisingly, this change in metabolism was sufficient to potentiate the sleep-inducing effects of the general anesthetic propofol in male rats (167)

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Inflammation is of particular pathophysiological relevance to lung diseases and cancer, as chronic bronchitis triggered by asbestos, silica, smoke, and other inhaled toxins results in a persistent inflammatory response, which significantly increases the risk for lung cancer [59]

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