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Importantly, even if one assumes the unlikely scenario wherein the CE4 device produced all dry-puffs at 7.3 W in every experiment (Table 1) in the current study, thereby inflating the levels of HCHO and 1a-d under conditions averse to users, the results of the replication study 4 show that a concerning percentage (12%) of human subjects could not detect dry puffs under conditions affording levels of formaldehyde that are above the OSHA threshold