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Forty-four RCTs were selected from a systematic review conducted by Lancaster et al.167, 268, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336 In addition, seven more recent RCTs were identified in an updated search,337, 338, 339, 340, 341, 342, 343 yielding a total of 51 RCTs included for data synthesis

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