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Molecular docking interactions of isoaromadendrene epoxide and epiglobulol with TMV-proteins The molecular docking tests of the active compounds showed that isoaromadendrene epoxide had the best affinity for binding to two viral target proteins (the coat and replicase large subunit proteins)

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As significant superoxide source, an uncoupled nitric oxide synthase was identified since a normalization of vascular dysfunction was achieved by administrating the eNOS cofactor tetrahydrobiopterin (BH 4 ) [37] (Fig