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Inflammatory endothelial cells enhance the expression of endothelial E- and P-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 ( Figs.1 and 3 ) , promoting the firm adhesion of platelets to inflammatory endothelium via interactions with platelet receptors, ultimately leading to the formation of occlusive intravascular thrombus 92 , 93)