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Census data for England and Wales (for years 1971, 1981, 1991 and 2001),22 scaled up to provide UK population estimates,23 were then interpolated between census years and combined with data on smoking prevalence and the proportion of smokers smoking HRT to generate estimates of the total number of smokers and the number smoking HRT in the UK, each year

A forest plot was generated for visualization, and the I 2 statistic was employed to assess study heterogeneity, indicating the percentage of variation due to heterogeneity rather than chance, with values ranging from 0 to 100% [39]

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