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Funding This work was supported in parts by NIH NIAID grant R01 AI131586, USDA-NIFA-Capacity Funds (Hatch and Animal Health), and the University of Minnesota School of Medicine Academic Investment Research Program (AIRP) and COVID-19 Rapid Response Funds to HL and YL, USDA-NIFA AFRI grant #2019-05384 and Minnesota Agricultural Experiment Station Rapid Agricultural Response Fund to HL, and by a pre-doctoral NIH fellowship T32 DA007097 to MB