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The general signs of these health problems in dogs typically include: Lethargy Depression Decreased appetite Rapid breathing High heart rate Panting Abdominal pain and enlarged abdomen Vomiting Drooling The gums, mucus membrane, and area around the eyes turn blue/chocolate brown Swelling in the face, paws, and forelimbs Dark urine Excessive thirst Hypothermia Excessive drooling Skin, face, and eyes discoloration Death Acetaminophen poisoning can also lead to keratoconjunctivitis in your dog, which you can recognize by the following signs: Red, painful eyes Squinting Eye discharge Pawing at the face/eyes Since some of these health problems caused by acetaminophen poisoning can develop rapidly, remember to stay calm but react promptly to help your dog have the highest chances of survival