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Buccal involvement is reported to be as high as 80 per cent of the cancers that arise at the site of placement of the tobacco-containing quid, mostly in the lower buccal sulcus or posterior buccal mucosa

In contrast, other cells of the body suffered only indirect damage, as tobacco smoking seems to affect key mechanisms in these cells that in turn mutate DNA. Joint lead author of the study from the Wellcome Trust Sanger Institute says, Our research indicates that the way tobacco smoking causes cancer is more complex than we thought

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