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Lung tumor and nontumor biospecimens from the NCI-MD cohort were collected according to procedures approved by the NCI, NIH, as described previously (21) (IRB OH98-C-N027)

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Interventions With Adequate Evidence of a Decreased Risk of Oral Cavity, Oropharyngeal, Hypopharyngeal, and Laryngeal Cancers Tobacco cessation Based on solid evidence, cessation of exposure to tobacco (e.g., cigarettes, pipes, cigars, and smokeless tobacco) leads to a decrease in the risk of oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers.[19] Magnitude of Effect : Decreased risk, moderate to large magnitude