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"Because of the direct link between nicotine itself and inflammation, this study has important implications including that alternative forms of nicotine inhalation, such as vaping that lacks other chemicals from cigarette smoke, may nonetheless still have detrimental immunological effects," explained E

In current clinical practice, the use of biologic agents largely relies on empirical judgment rather than stratification based on immunological characteristics, resulting in a trial-and-error approach to treatment that often delays optimal intervention (188)