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While these studies are often conducted in vitro (not on living teeth), they highlight the potential for harm, especially when products are used incorrectly or in excessive concentrations

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These labels are so problematic that the Food and Drug Administration has required Santa Fe Natural Tobacco Company, the maker of Natural American Spirit cigarettes, to remove the terms natural and additive-free from its product labels, advertising and promotional materials because they constitute reduced harm claims, which are banned without agency approval