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1915 : The American Tobacco Company was the first to introduce the flip-top cigarette pack, which became an instant hit due to its convenience and the flip closure that kept cigarettes fresh

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"In short, these relationships are most likely correlative, and they are often complex, multi-directional, and they are far from unique to cannabis." Some populations, however, are more vulnerable to cannabis effects, particularly when the substance is used frequently or at earlier ages, Armentano noted