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In 2015, we used hyperinsulinaemiceuglycaemic clamps coupled with stable isotope tracers to measure hepatic glucose output and indirect calorimetry to measure substrate utilization, as part of a study that enrolled healthy smokers who smoked between half a pack and two packs per-day in an 8-week smoking cessation program of behavioural counseling plus oral bupropion (phase I) 105