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Long-term use of e-cigarettes increases lung inflammation levels, including macrophages, neutrophils, eosinophils, and basophils, promotes the migration and infiltration of inflammatory cells from the blood to the respiratory tract, stimulates the production of Th2-related cytokines (IL-4, IL-5, IL-13), and exacerbates inflammation [40, 49]

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[126] [127] Opium smoking later spread with Chinese immigrants and spawned many infamous opium dens in Chinatowns around South and Southeast Asia, Europe and the Americas