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In a comparative study, repeated exposure of human gingival fibroblasts to CS condensate or to nicotine-rich or nicotine-free e-vapour condensates led to alterations in morphology, suppression of proliferation and induction of apoptosis, with changes in all three parameters greater in cells exposed to CS condensate [29]

The mixture of carcinogens in tobacco smoke causes DNA damage and mutations, promoting tumor development in multiple organs, including the lungs, bladder, and oral cavity